ea0059oc4.2 | Clinical highlights | SFEBES2018
Chia Eng Pei
, Abbara Sophie Clarke Ali
, Phylactou Maria
, Mills Edouard
, Koteshwara Muralidhara
, Chia Germaine
, Yang Lisa
, Pratibha Machenahalli C
, Papadopoulou Deborah
, Izzy-Engbeaya Chioma
, Jayasena Channa
, Comninos Alexander N
, Dhillo Waljit S
Background: Hypogonadotrophic Hypogonadism (HH) is characterised by hypogonadism in the context of low gonadotrophin levels, frequently due to a defect in hypothalamic function e.g. Kallmans syndrome. However, no direct test of hypothalamic function currently exists. Kisspeptin is a hypothalamic neuropeptide that stimulates endogenous GnRH release. Thus, we investigated whether kisspeptin could be used to interrogate hypothalamic function in men with HH.<p class="abs...